Pleiotropic Role of Notch Signaling in Human Skin Diseases

The document reviewed the pleiotropic role of Notch signaling in various human skin diseases, such as Hidradenitis Suppurativa, Dowling Degos Disease, Adams–Oliver Syndrome, Psoriasis, and Atopic Dermatitis. Notch signaling was crucial for regulating cell proliferation, differentiation, migration, and apoptosis in epidermal cells. Disruptions in this pathway, due to mutations or gene regulation issues, could lead to skin diseases through hyper- or hypo-activation of Notch molecules and target genes. The review highlighted the complex interplay between genetic mutations and Notch signaling, emphasizing its critical role in skin disease pathogenesis and potential as a therapeutic target. The document also noted the need for further studies to clarify the complex and sometimes contradictory findings related to Notch signaling in skin disorders.