TLDR Notch signaling disruptions can cause various skin diseases.
The document reviewed the pleiotropic role of Notch signaling in various human skin diseases, such as Hidradenitis Suppurativa, Dowling Degos Disease, Adams–Oliver Syndrome, Psoriasis, and Atopic Dermatitis. Notch signaling was crucial for regulating cell proliferation, differentiation, migration, and apoptosis in epidermal cells. Disruptions in this pathway, due to mutations or gene regulation issues, could lead to skin diseases through hyper- or hypo-activation of Notch molecules and target genes. The review highlighted the complex interplay between genetic mutations and Notch signaling, emphasizing its critical role in skin disease pathogenesis and potential as a therapeutic target. The document also noted the need for further studies to clarify the complex and sometimes contradictory findings related to Notch signaling in skin disorders.
40 citations,
January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
61 citations,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
253 citations,
April 2008 in “Current opinion in cell biology” Notch signalling helps skin cells differentiate and prevents tumors.
1 citations,
April 2018 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia” Hidradenitis suppurativa is a chronic skin condition more common in women, linked to genetics and lifestyle factors, and associated with various other health issues.
78 citations,
October 2020 in “Experimental Dermatology” Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.
Hidradenitis Suppurativa has genetic links, with certain gene mutations more common in patients and a third of cases having a family history.
13 citations,
September 2022 in “Biomolecules” The research confirms that Hidradenitis Suppurativa is characterized by increased inflammation, disrupted skin cell organization, and abnormal metabolic processes.
29 citations,
March 2019 in “British Journal of Dermatology” Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
