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Glossary Inflammatory Lesions

areas of tissue that are swollen, red, and painful

Inflammatory lesions are areas of tissue that have become swollen, red, and painful due to the body's immune response to injury, infection, or irritation. These lesions can occur in various parts of the body, including the skin, and are often characterized by the presence of immune cells and inflammatory mediators that aim to protect and heal the affected area.

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Research

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Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

278 citations , March 2013 in “Gut”

In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.

Prevalence of Skin Lesions in Brazilian Patients With Inflammatory Bowel Disease

research Prevalence of skin lesions in a sample of Brazilian patients with inflammatory bowel disease

January 2023 in “Revista da Associação Médica Brasileira”

In this study, Brazilian patients with inflammatory bowel diseases had a higher prevalence of skin lesions, including alopecia, xerosis, striae, and acne, compared to healthy controls.

research Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

25 citations , December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This study suggests that targeting specific immune pathways, such as IL-12/23 and Th2 cytokines, may offer new treatment options for alopecia areata, a T-cell-mediated disease without current mechanism-specific therapies.

Dermoscopy for the Pediatric Dermatologist Part I: Dermoscopy of Pediatric Infectious and Inflammatory Skin Lesions and Hair Disorders

research Dermoscopy for the Pediatric Dermatologist Part I: Dermoscopy of Pediatric Infectious and Inflammatory Skin Lesions and Hair Disorders

66 citations , February 2013 in “Pediatric Dermatology”

This review summarizes the dermoscopic structures associated with infectious and inflammatory skin conditions and hair disorders in children but reports no new clinical results.

research The spectrum of inflammatory skin disease following jejuno-ileal bypass for morbid obesity

51 citations , October 1981 in “British Journal of Dermatology”

This study found that in patients who underwent jejuno-ileal bypass for morbid obesity, dapsone was effective in treating inflammatory skin lesions and joint symptoms when other antibiotics failed.

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Community Join

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community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1391 upvotes 1 year ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Has anyone tried nicotinamide serum for inflammatory hair loss.

3 upvotes 1 year ago

Nicotinamide serum is discussed for its potential benefits in reducing inflammation related to hair loss. One user combines it with minoxidil for hair growth.

community Any chances of my hairloss being inflammatory?

5 upvotes 5 days ago

A 20-year-old male has been experiencing hair loss since age 15-16 and is using oral minoxidil, dutasteride, and ketoconazole shampoo, with previous use of oral finasteride and topical minoxidil. He has stabilized hair loss but seeks to rule out inflammatory or immune-related causes, considering a scalp biopsy, and is supplementing with vitamin D3, B12, and iron.

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Learn

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learn Fluocinolone

Is Fluocinolone a treatment for hair loss itself or just for calming scalp irritation? Fluocinolone acetonide is a prescription corticosteroid approved for inflammatory skin conditions, not for hair loss; no published human trial has measured hair regrowth with it, so at most it may help indirectly by calming an inflamed scalp.

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

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Noelle Skin
Nice, France

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