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Glossary Psoriatic Lesions

inflamed, red, and scaly skin patches from an overactive immune response

Psoriatic lesions, also known as psoriasis plaques, are areas of inflamed, red, and scaly skin that occur due to an overactive immune response. These lesions are characterized by an accelerated skin cell turnover, leading to the buildup of thick, silvery scales and itchy, dry patches that can be painful. They commonly appear on the elbows, knees, scalp, and lower back, but can affect any part of the body.

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research Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions

10 citations , January 2016 in “Dermatology”

This study found a significant reduction in the number and size of sebaceous glands in psoriatic skin lesions, indicating potential involvement in psoriatic alopecia.

research Amelioration of psoriasis-like skin lesions by human amniotic mesenchymal stem cells: insights from multiomics profiling in mice

February 2026 in “Frontiers in Immunology”

This study found that administering human amniotic mesenchymal stem cells (hAMSCs) in a mouse model of psoriasis improved skin lesions and reduced inflammation-related markers, suggesting potential therapeutic benefit and safety for treating psoriasis, and identified specific gene targets involved in the treatment's mechanism.

research Psoriatic Skin Lesions Induced by Certolizumab Pegol

21 citations , September 2010 in “Archives of Dermatology”

This document provides a legal disclaimer and offers no research findings.

research Re-investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis?

13 citations , June 2018 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry”

This study found that the expression of laminin-511 and -332 was significantly increased in psoriasis skin lesions and may influence keratinocyte proliferation and apoptosis, suggesting a previously overlooked role in the disease's pathogenesis.

research Interleukin 17 Expression in Psoriatic Skin Lesions before and after Treatment with Platelet Rich Plasma (PrP)

2 citations , June 2018 in “The Medical Journal of Cairo University/The Medical Journal of Cairo University”

This study found that while Platelet Rich Plasma injections led to some clinical and immunological improvements in psoriatic plaques, it could not be recommended as a standalone treatment for localized plaque psoriasis.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Scalp Psoriasis and Fin/Min options?

in Treatment 3 upvotes 8 months ago

A user with scalp psoriasis and hair loss is hesitant to use topical minoxidil and finasteride due to concerns about psoriasis and potential side effects. They are considering alternatives like pumpkin seed and saw palmetto.

community 33M Medication w/scalp psoriasis

in Progress Pictures 1 upvotes 5 months ago

A 33-year-old male restarted finasteride after stopping it to conceive, noticing hair loss, especially in the crown area. His current routine includes finasteride, minoxidil, ketoconazole, and microneedling, and he plans to continue this treatment for 18 months before making any major changes.

community Scalp Inflammation Beyond Psoriasis: A Hidden Player in Hair Thinning

in Technology 54 upvotes 5 months ago

Scalp inflammation may contribute to hair thinning, with treatments like ketoconazole shampoo potentially helping by reducing inflammation. Some users report that DHT blockers and other treatments like finasteride, minoxidil, and RU58841 can alleviate symptoms associated with inflammation.

community Can someone with psoriasis use minoxidil?

in Minoxidil 22 upvotes 1 year ago

A user with psoriasis is unsure if they can safely use minoxidil for hair loss. They are seeking advice on its safety for their condition.

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