Biomechanical Factors in Psoriatic Disease: Defective Repair Exertion as a Potential Cause. Hypothesis Presentation and Literature Review

The document hypothesized that defective repair processes in psoriatic disease could lead to immune activation and autoinflammatory lesions, particularly in the context of nail lesions and psoriatic arthritis. It suggested that repetitive microdamage might trigger these conditions, with the nail being a frequently traumatized structure. The study highlighted the role of mechanosensitive Wnt signaling, particularly Wnt5a, in the pathophysiology of psoriasis and ankylosing spondylitis, suggesting it as a potential link between mechanical stress and psoriatic responses. The authors recommended future research to explore the complex interactions of tissue repair regulators in psoriatic disease.