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This review explores the biomechanical factors and signaling systems, like Wnt, involved in the pathophysiology of psoriatic nail lesions and reports no new results.

Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.

In this study, enteroendocrine cells were shown to coordinate intestinal stem cell migration towards a wound in Drosophila by releasing a ligand that activates non-canonical Wnt signaling, aiding efficient tissue repair.

Wnt signaling helps regenerate hair follicles in wounds by reducing skin cell sensitivity to mechanical stress.

This study found that occlusive dressings on mouse wounds eliminated wound-induced hair neogenesis by upregulating mechanotransduction, which promotes fibrosis, and suppressing Wnt signaling involved in regeneration.