Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders

    January 2025 in “ International Journal of Molecular Sciences ”
    Olguța Anca Orzan, Cristina Violeta Tutunaru, Simona Laura Ianoși
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    TLDR Psoriasis involves immune and genetic factors, and understanding these can improve treatments.
    The document delves into the intricate pathophysiology of psoriasis and its association with various skin disorders, emphasizing the role of immune dysregulation and genetic factors. Psoriasis affects 2-3% of the global population and shares mechanisms with conditions like alopecia areata and vitiligo, involving cytokines such as IL-17 and IL-23. The study highlights the importance of understanding shared pathways, such as T cell dysfunction and autophagy, to improve treatment strategies. It also discusses the potential benefits of therapies like omalizumab and biologics, while noting the need for further research into the co-occurrence of psoriasis with other autoimmune disorders and the impact of environmental factors like stress and the skin microbiome.
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