TLDR Psoriasis involves immune and genetic factors, and understanding these can improve treatments.
The document delves into the intricate pathophysiology of psoriasis and its association with various skin disorders, emphasizing the role of immune dysregulation and genetic factors. Psoriasis affects 2-3% of the global population and shares mechanisms with conditions like alopecia areata and vitiligo, involving cytokines such as IL-17 and IL-23. The study highlights the importance of understanding shared pathways, such as T cell dysfunction and autophagy, to improve treatment strategies. It also discusses the potential benefits of therapies like omalizumab and biologics, while noting the need for further research into the co-occurrence of psoriasis with other autoimmune disorders and the impact of environmental factors like stress and the skin microbiome.
45 citations
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May 2024 in “International Journal of Molecular Sciences” Alopecia areata is caused by immune attacks on hair follicles, affecting hair growth and quality of life.
35 citations
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February 2023 in “Biomolecules” 
8 citations
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July 2022 in “Biomedicines” Autophagy helps keep skin healthy and may improve treatments for skin diseases.
144 citations
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November 2020 in “Frontiers in immunology” Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.
59 citations
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June 2022 in “Frontiers in medicine” There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
March 2024 in “Current issues in molecular biology” Personalized medicine in dermatology uses molecular biomarkers to improve diagnosis and treatment but needs further advancements for practical use.
April 2024 in “International journal of molecular sciences” Alopecia areata and vitiligo share immune system dysfunction but differ in specific immune responses and affected areas.
24 citations
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March 2018 in “Experimental Dermatology” Treg dysfunction is linked to various autoimmune skin diseases, and understanding Treg properties is key for new treatments.
37 citations
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January 2016 in “Drug design, development and therapy” Tofacitinib citrate is effective for moderate-to-severe chronic plaque psoriasis but has safety concerns at higher doses.
August 2024 in “Bioscience of Microbiota Food and Health” Microbes might play a role in vitiligo.
