The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

The IL-23/IL-17 pathway played a crucial role in the pathogenesis of various inflammatory skin diseases, including psoriasis, atopic dermatitis, hidradenitis suppurativa, alopecia areata, pityriasis rubra pilaris, pemphigus, and systemic sclerosis. IL-17, primarily secreted by Th17 cells, was stimulated by IL-23. Clinical trials demonstrated that monoclonal antibodies targeting IL-23, IL-17, and tumor necrosis factor were effective treatments for these conditions. The document summarized the biology, signaling, and pathophysiological functions of the IL-23/IL-17 axis and discussed the available biologics targeting this pathway.