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GlossaryT helper 17 cells (Th17 cells)

specialized immune cells involved in inflammation and autoimmune responses

T helper 17 cells, often abbreviated as Th17 cells, are a subset of T cells, which are a type of white blood cell crucial for the immune system. Th17 cells play a key role in defending the body against bacterial and fungal infections by producing a specific set of signaling molecules called cytokines, particularly interleukin-17 (IL-17). They are also involved in inflammatory responses and have been implicated in various autoimmune diseases, where the immune system mistakenly attacks the body's own tissues.

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Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

278 citations, March 2013 in “Gut”

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

research Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

4 citations, January 2011 in “Journal of UOEH”

Autoimmune hair loss may be linked to increased Th1 and Th17 cells and decreased Th2 cells.

Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

research Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

31 citations, February 2014 in “Inflammation Research”

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

18 citations, January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata

62 citations, June 2015 in “The Journal of Dermatology”

People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.

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