Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies

March 2024 in “ Current issues in molecular biology ”

Isabella J. Tan, Alicia Podwojniak, Ameet Parikh, Bernard A. Cohen

alopecia areata psoriasis hidradenitis suppurativa TNF-α IL-1β lipocalin-2 JAK inhibitors adalimumab AI nanotechnology multi-omics AA HS tumor necrosis factor-alpha interleukin-1 beta Janus kinase inhibitors Humira artificial intelligence

TLDR Personalized medicine in dermatology uses molecular biomarkers to improve diagnosis and treatment but needs further advancements for practical use.

The review "Precision Dermatology: A Review of Molecular Biomarkers and Personalized Therapies" highlights the transformative impact of molecular biomarkers in diagnosing, staging, and treating dermatological conditions such as alopecia areata (AA), psoriasis, and hidradenitis suppurativa (HS). Key biomarkers like TNF-α, IL-1β, and lipocalin-2 inform targeted therapies, including JAK inhibitors for AA and adalimumab for HS. Despite some biomarkers being more scientifically valuable than clinically practical, advancements in AI, nanotechnology, and multi-omics hold promise for enhancing personalized dermatological care, ultimately improving patient outcomes and treatment efficacy.

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