Personalized Medicine in the Field of Inflammatory Skin Disorders

    Mircea Tampa, Monica Neagu, Constantin Căruntu, Simona Roxana Georgescu
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    TLDR Personalized medicine is important for treating skin disorders, with new treatments and connections to hormones and genetics being explored.
    The document discusses the importance of personalized medicine in treating inflammatory skin disorders like psoriasis and atopic dermatitis. A study by Nicolescu et al. used a questionnaire to estimate psoriasis prevalence and risk factors in Romania, with a 99.13% match between questionnaire diagnosis and final diagnosis. Sobolev et al. found that low estrogen levels can influence psoriasis in women due to the differential expression of six estrogen-controlled genes. For atopic dermatitis treatment, Janus kinase inhibitors (JAK) are emerging as effective with tolerable side effects, as shown in a systematic review by Tsai et al. The document also explores novel biomarkers in connective tissue diseases, the connection between inflammation and skin tumors, and the role of cannabinoids in inflammation. A meta-analysis by Georgescu et al. found a significant positive correlation between the number of platelet-rich plasma treatments per month and the percentage change in hair density in patients with androgenic alopecia.
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