Effect of PTPN22, FAS/FASL, IL2RA, and CTLA4 Genetic Polymorphisms on Alopecia Areata Risk: Systematic Review and Meta-Analysis

    November 2021 in “ PLoS ONE ”
    Sebastián Ramiro Gil-Quiñones, I. T. Sepúlveda-Pachón, Guillermo Sánchez, Luz Dary Gutiérrez-Castañeda
    Studysummary This study suggests that the T allele of the SNP rs2476601 in the PTPN22 gene may increase the risk of alopecia areata, although further studies are necessary to validate this finding across different populations.
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    Research cited in this study 10

    1. Association of Rs231775 Genetic Variant of Cytotoxic T-Lymphocyte Associated Protein 4 with Alopecia Areata Disease in Males: A Case-Control Study Immunological Investigations · 2020
    2. CTLA4 +49AG (rs231775) And CT60 (rs3087243) Gene Variants Are Not Associated With Alopecia Areata In A Mexican Population From Monterrey, Mexico Anais Brasileiros de Dermatologia · 2020
    3. The Association Between rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata Medicine · 2019
    4. Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata Journal of Investigative Dermatology · 2015
    5. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    6. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    7. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    8. Genetic Basis of Alopecia Areata Dermatologic clinics · 2012
    9. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    10. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010

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