Effect of PTPN22, FAS/FASL, IL2RA, and CTLA4 Genetic Polymorphisms on Alopecia Areata Risk: Systematic Review and Meta-Analysis

November 2021 in “ PLoS ONE ”

Sebastián Ramiro Gil-Quiñones, I. T. Sepúlveda-Pachón, Guillermo Sánchez, Luz Dary Gutiérrez-Castañeda

alopecia areata PTPN22 FAS FASL IL2RA CTLA4 rs2476601 gene polymorphisms T allele SNP AA single nucleotide polymorphism

Studysummary This study suggests that the T allele of the SNP rs2476601 in the PTPN22 gene may increase the risk of alopecia areata, although further studies are necessary to validate this finding across different populations.

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research Association of Rs231775 Genetic Variant of Cytotoxic T-Lymphocyte Associated Protein 4 with Alopecia Areata Disease in Males: A Case-Control Study

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research CTLA4 +49AG (rs231775) And CT60 (rs3087243) Gene Variants Are Not Associated With Alopecia Areata In A Mexican Population From Monterrey, Mexico

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research The Association Between rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata

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This meta-analysis found that the rs2476601 SNP of the PTPN22 gene is significantly associated with reduced susceptibility to alopecia areata, with carriers of the C-allele and CC-genotype having a lower risk.

research Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata

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research The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives

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This article proposes that alopecia areata may be caused by immune attacks on hair follicles after an immune privilege collapse, suggesting new therapeutic approaches targeting this immune response pattern.

research Genetic Basis of Alopecia Areata

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research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

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research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

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