The Association Between rs2476601 Polymorphism in PTPN22 Gene and Risk of Alopecia Areata

May 2019 in “ Medicine ”

Zixian Lei, Wenjing Chen, Junqin Liang, Li Wang, Lan Jin, Xu Chen, Xiaojing Kang

rs2476601 polymorphism PTPN22 gene alopecia areata AA C-allele CC-genotype single nucleotide polymorphism SNP

Studysummary This meta-analysis found that the rs2476601 SNP of the PTPN22 gene is significantly associated with reduced susceptibility to alopecia areata, with carriers of the C-allele and CC-genotype having a lower risk.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on journals.lww.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.

research Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis

128 citations , February 2016 in “British Journal of Dermatology”

This study found that patients with alopecia areata experience significant impairments in health-related quality of life, notably affecting mental health, according to various quality of life assessment tools.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research Update on the Treatment of Alopecia Areata

11 citations , May 2009 in “Actas Dermo-Sifiliográficas”

This review discusses various therapeutic options for alopecia areata and reports no new clinical results; treatments may manage symptoms but do not cure the condition.