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GlossaryCytotoxic T-Lymphocyte Antigen 4 (CTLA4)

regulates immune response by inhibiting T cell activation

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) is a protein found on the surface of T cells, which are a type of immune cell. It acts as an "off switch" to help regulate the immune system by preventing it from attacking the body's own tissues. This protein is crucial in maintaining immune tolerance and preventing autoimmune diseases.

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research CTLA4 +49AG (rs231775) And CT60 (rs3087243) Gene Variants Are Not Associated With Alopecia Areata In A Mexican Population From Monterrey, Mexico

6 citations, March 2020 in “Anais Brasileiros de Dermatologia”

CTLA4 gene variants are not linked to alopecia areata in Monterrey's Mexican population.

The Cutaneous Side Effects of Selective BRAF Inhibitors and Anti-CTLA4 Agents: The Growing Role of the Dermatologist in the Management of Patients with Metastatic Melanoma

research The Cutaneous Side Effects of Selective BRAF Inhibitors and Anti-CTLA4 Agents: The Growing Role of the Dermatologist in the Management of Patients with Metastatic Melanoma

6 citations, April 2013 in “Current Dermatology Reports”

Dermatologists are crucial for managing skin side effects in metastatic melanoma patients using vemurafenib and ipilimumab.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations, June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

research Genetic Basis of Alopecia Areata

40 citations, October 2012 in “Dermatologic clinics”

More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.

research Psoriasis Is Characterized by Deficient Negative Immune Regulation Compared to Transient Delayed-Type Hypersensitivity Reactions

15 citations, June 2015 in “F1000Research”

Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.

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