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GlossaryCytotoxic T-Lymphocyte Antigen 4 (CTLA4)

regulates immune response by inhibiting T cell activation

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) is a protein found on the surface of T cells, which are a type of immune cell. It acts as an "off switch" to help regulate the immune system by preventing it from attacking the body's own tissues. This protein is crucial in maintaining immune tolerance and preventing autoimmune diseases.

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research Genetic Basis of Alopecia Areata

40 citations , October 2012 in “Dermatologic clinics”

More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.

research Identification of Differentially Expressed miRNAs in Alopecia Areata That Target Immune-Regulatory Pathways

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers found that certain miRNAs, which affect immune system regulation, are differently expressed in mice with a hair loss condition compared to healthy mice.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.

research Genetics of Alopecia

April 2012 in “Encyclopedia of Life Sciences”

Different genes are linked to various types of hair loss.

research Psoriasis Is Characterized by Deficient Negative Immune Regulation Compared to Transient Delayed-Type Hypersensitivity Reactions

15 citations , June 2015 in “F1000Research”

Psoriasis may be chronic because it lacks certain immune system controls that prevent overreaction.

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