4 citations
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October 2022 in “Medicine” Vitamin D might help treat alopecia areata.
3 citations
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October 2022 in “Journal of Cosmetic Dermatology” This study found that alopecia areata patients had a higher serum CRP/albumin ratio compared to healthy controls, and this elevation was linked to disease severity, indicating its potential as an inflammatory marker.
7 citations
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February 2022 in “Journal of Cosmetic Dermatology” In this randomized controlled trial, intralesional vitamin D3 injections significantly improved localized alopecia areata symptoms compared to a saline placebo, with minimal and transient side effects, suggesting vitamin D3 as an effective treatment option without needing prior serum vitamin D level measurement.
37 citations
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December 2021 in “Cells” This study found that dysregulation of systemic Th1, Th2, and Th17 cytokines is associated with alopecia areata, with specific cytokines linked to disease activity and treatment response.
6 citations
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October 2021 in “Biomedical Research and Therapy” This meta-analysis found that alopecia areata patients had significantly higher serum levels of IL-6 and TNF-α compared to healthy subjects, indicating a potential role of these cytokines in the condition's pathogenesis.
130 citations
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February 2019 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study found that JAK inhibitors for alopecia areata showed promising response rates, with 72.4% of 289 cases responding, and oral administration achieving better outcomes than topical treatment, but recurrence occurred when treatment stopped. Further large-scale studies are needed to confirm these findings.
17 citations
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January 2019 in “Annals of Dermatology” This study found that higher serum CXCL10 levels may predict the progression of non-segmental vitiligo, especially in patients also suffering from autoimmune thyroid disease and/or alopecia areata.
7 citations
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January 2019 in “Indian dermatology online journal” In this study, significantly lower serum vitamin D levels were observed in patients with alopecia areata compared to healthy controls, with an inverse correlation between vitamin D levels and disease severity or duration.
58 citations
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July 2018 in “Journal of Allergy and Clinical Immunology” Alopecia areata severity is linked to increased TH1 and TH2 activity.
37 citations
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June 2018 in “Clinical and Experimental Medicine” This study found that patients with alopecia areata had significant systemic inflammation and vitamin D deficiency, with both conditions more pronounced as disease severity increased.
29 citations
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December 2017 in “International Journal of Dermatology” This study found that vitamin D deficiency in patients with alopecia areata was associated with greater disease severity and longer duration, but not with disease pattern or vitamin D receptor expression.
99 citations
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July 2017 in “Clinical Reviews in Allergy & Immunology” This review noted that alopecia areata is an autoimmune disease impacting hair follicles and offered insights into its complex pathogenesis involving immune responses, while highlighting ongoing research into new treatments such as Janus kinase inhibitors and other immunomodulatory drugs.
13 citations
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March 2014 in “Journal of Clinical Laboratory Analysis” This study found that patients with alopecia areata had significantly higher serum MIF levels compared to healthy controls, which correlated with greater disease severity and duration.
105 citations
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March 2014 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, patients with alopecia areata were found to have significantly lower serum vitamin D levels compared to those with vitiligo and healthy individuals, with lower levels correlating with increased disease severity.
6 citations
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June 2011 in “British Journal of Dermatology” This study found that individuals with alopecia areata had significantly higher serum levels of retinol-binding protein 4 and increased IgG immunoreactivity against it, suggesting a role in the disease's pathogenesis.
