Serum Level of Macrophage Migration Inhibitory Factor in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease

    March 2014 in “ Journal of Clinical Laboratory Analysis ”
    Doreen N. Younan, Naglaa Agamia, Adel Elshafei, Nancy Ebeid
    TLDR Higher MIF levels in alopecia areata patients suggest it could be a treatment target and disease predictor.
    The study investigated the role of macrophage migration inhibitory factor (MIF) in alopecia areata (AA) by measuring serum MIF levels in 31 AA patients and 15 healthy controls. Results showed significantly higher MIF levels in AA patients, with a positive correlation between MIF levels, clinical severity, and disease duration. The findings suggested that MIF played a crucial role in the pathogenesis of AA, indicating its potential as a therapeutic target and predictor of disease activity. Anti-MIF therapy was proposed as a possible new treatment for AA.
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