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GlossaryMacrophage Migration Inhibitory Factor (MIF)

protein that regulates immune responses and inflammation

Macrophage Migration Inhibitory Factor (MIF) is a protein that plays a crucial role in the immune system by regulating inflammation and immune responses. It inhibits the movement of macrophages, which are cells that engulf and digest pathogens and cellular debris, thereby helping to control the body's inflammatory response. MIF is also involved in various diseases, including autoimmune disorders and cancer, making it a significant target for medical research.

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research Increased Macrophage Migration Inhibitory Factor in the Sera of Patients with Extensive Alopecia Areata

14 citations, March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Patients with severe alopecia areata have higher levels of MIF, which decrease after successful treatment.

research Serum Level of Macrophage Migration Inhibitory Factor in Egyptians With Alopecia Areata and Its Relation to the Clinical Severity of the Disease

13 citations, March 2014 in “Journal of Clinical Laboratory Analysis”

Higher MIF levels in alopecia areata patients suggest it could be a treatment target and disease predictor.

research Etiopathogenesis of Alopecia Areata

2 citations, February 2014 in “Hair therapy & transplantation”

Alopecia Areata is an autoimmune condition causing hair loss, influenced by genetics, environment, and possibly improved by anti-MIF therapy, with many patients experiencing regrowth within a year.

Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

research Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

38 citations, April 2018 in “Psychopharmacology/Psychopharmacologia”

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

research Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth

19 citations, May 2020 in “Cells”

Substance from human umbilical cord blood cells promotes hair growth.

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community The story of RU58841/ PSK3841

in Research 622 upvotes 5 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

community 4 months on 2.5 mg OM, no improvement

in Minoxidil 6 upvotes 2 years ago

After 4 months on oral minoxidil with no significant hair regrowth, a user is frustrated and considering alternative treatments since they can't take finasteride due to side effects. Suggestions include natural DHT blockers, lifestyle changes, and other hair care tips.

community Are permanent hair gains even possible?

in Chat 12 upvotes 2 months ago

Hair regrowth from treatments like minoxidil, RU58841, and finasteride is not permanent; stopping these treatments typically results in hair loss resuming. Beard hair can become permanent with minoxidil use, unlike scalp hair, which requires ongoing treatment to maintain gains.

community F the big 3, it's just big me!

in Satire 670 upvotes 8 months ago

The conversation discusses hair loss treatments, with users mentioning dutasteride (Dut) as effective and wishing for more accessible dosages. They also debate the components of the "big 3" treatments, which now include Dut, RU58841, and oral minoxidil, with finasteride and minoxidil being consistently mentioned.