Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

    January 2016 in “ Cell reports ”
    Kai Kretzschmar, Christine Weber, Ryan R. Driskell … Fiona M. Watt
    Studysummary This study found that different epidermal stem cell populations contribute to the formation of various skin tumors and new hair follicles following β-catenin activation in the adult epidermis.
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    Research cited in this study 23

    1. The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells Journal of Investigative Dermatology · 2015
    2. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    3. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    4. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    5. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    6. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    7. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    8. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    9. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    10. Differential Sensitivity of Epidermal Cell Subpopulations to Beta-Catenin-Induced Ectopic Hair Follicle Formation Developmental Biology · 2010
    11. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    12. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    13. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    14. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    15. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    16. Role of β-Catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer Cold Spring Harbor Symposia on Quantitative Biology · 2008
    17. Epithelial Stem Cells: Turning Over New Leaves Cell · 2007
    18. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    19. Defining the Impact of Beta-Catenin/Tcf Transactivation on Epithelial Stem Cells Genes & development · 2005
    20. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    21. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    22. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    23. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001

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