Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

    January 2016 in “ Cell reports ”
    Kai Kretzschmar, Christine Weber, Ryan R. Driskell, Eduardo Calonje, Fiona M. Watt
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    TLDR Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
    The 2016 study by Kretzschmar et al. explored the effects of β-catenin activation in various epidermal stem cell populations on hair follicle formation and skin tumor development. They discovered that activation in LGR6+ and LRIG1+ stem cells led to ectopic hair follicles in the sebaceous gland, while LGR5+ cells did not contribute to this process. Instead, activation in LGR5+ cells resulted in pilomatricomas, LRIG1+ cells in trichoadenomas, and LGR6+ cells in dermatofibromas, each with distinct stromal characteristics. The study, which involved 3 to 5 mice per condition and time point, concluded that the specific compartment of epidermal stem cells where β-catenin is activated determines the type of skin tumor that forms, highlighting the importance of cellular origin in tumor heterogeneity.
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