Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity
January 2016
in “
Cell reports
”
TLDR Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
The 2016 study by Kretzschmar et al. explored the effects of β-catenin activation in various epidermal stem cell populations on hair follicle formation and skin tumor development. They discovered that activation in LGR6+ and LRIG1+ stem cells led to ectopic hair follicles in the sebaceous gland, while LGR5+ cells did not contribute to this process. Instead, activation in LGR5+ cells resulted in pilomatricomas, LRIG1+ cells in trichoadenomas, and LGR6+ cells in dermatofibromas, each with distinct stromal characteristics. The study, which involved 3 to 5 mice per condition and time point, concluded that the specific compartment of epidermal stem cells where β-catenin is activated determines the type of skin tumor that forms, highlighting the importance of cellular origin in tumor heterogeneity.
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12 / results
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research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin
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research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin
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research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
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research Epidermal Stem Cell Diversity and Quiescence
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research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells
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2 / results
research LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis
LGR5 is a common marker of hair follicle stem cells in different animals and is important for hair growth and regeneration.
research LGR5 Is a Conserved Marker of Hair Follicle Stem Cells Across Species and Is Present Early and Throughout Follicle Morphogenesis
LGR5 is a marker found in hair follicle stem cells in various species and is important for hair growth and skin repair.