LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis

    June 2022 in “ Scientific Reports ”
    Kathryn M. Polkoff, Nithin Gupta, Adrian Green … Jorge A. Piedrahita
    Studysummary Using a transgenic pig model, this study demonstrated that LGR5 is a marker of hair follicle stem cells across different species, with important similarities and differences in gene expression and developmental processes.
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    Research cited in this study 18

    1. Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding Seminars in Cell & Developmental Biology · 2019
    2. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    3. The Hair Follicle as a Wound Healing Promoter and Its Application in Clinical Practice 2017
    4. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    5. Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss Nature Cell Biology · 2017
    6. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    7. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    8. The Immunology of the Porcine Skin and Its Value as a Model for Human Skin Molecular immunology · 2014
    9. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    10. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    11. Biochemistry of Epidermal Stem Cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012
    12. Ferreting Out Stem Cells From Their Niches Nature Cell Biology · 2011
    13. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    14. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    15. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2006
    16. Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    17. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    18. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004

    Related research 2

    1. LGR5 Is a Conserved Marker of Hair Follicle Stem Cells in Multiple Species and Is Present Early and Throughout Follicle Morphogenesis Scientific Reports · 2022
    2. LGR5 Is a Conserved Marker of Hair Follicle Stem Cells Across Species and Is Present Early and Throughout Follicle Morphogenesis Research Square (Research Square) · 2022