TLDR Porcine skin is very similar to human skin, making it a useful model for research.
The document reviewed the immunological properties of porcine skin, emphasizing its structural and compositional similarities to human skin, making it a valuable pre-clinical model for dermatological research. It focused on dendritic cells (DCs) in pig skin, proposing classifications for porcine DC subsets that corresponded to human DC subsets based on specific phenotypic markers. The review highlighted the pig's utility in studying skin immunology, wound healing, transdermal delivery, and other dermatological areas, and suggested future studies to confirm these findings through transcriptomic analysis.
1160 citations,
November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
31 citations,
August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
47 citations,
July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
2 citations,
October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
132 citations,
January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
