LGR5 Is a Conserved Marker of Hair Follicle Stem Cells Across Species and Is Present Early and Throughout Follicle Morphogenesis
February 2022
in “
Research Square (Research Square)
”
Studysummary This study demonstrated that LGR5 is a marker of hair follicle stem cells across species using a transgenic pig model and noted similarities and differences in expression patterns compared to humans. Our plain-language summary of this paper — not a Tressless recommendation.
The document discusses the role of LGR5 as a marker of hair follicle stem cells across different species, including humans and pigs. The study used a transgenic pig model, which is a widely accepted model for human skin and skin repair. The findings show that LGR5 is present in hair follicle stem cells during both homeostasis and development. The study also highlights the strong similarities and key differences in expression patterns, gene expression profiles, and developmental processes between species. This information is crucial for understanding the fundamental differences and similarities across species, and could potentially enhance human hair follicle regeneration, cutaneous wound healing, and skin cancer treatment.
