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GlossaryPilomatricoma

benign skin tumor originating from hair follicle matrix cells

Pilomatricoma, also known as Calcifying Epithelioma of Malherbe or Pilomatrixoma, is a benign skin tumor that originates from hair follicle matrix cells. It typically presents as a firm, painless lump under the skin, often on the face, neck, or arms, and can sometimes become calcified. While it is generally non-cancerous, surgical removal is usually recommended to prevent potential complications.

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research Polyomavirus-Induced Pilomatricomas in Mice: From Viral Inoculation to Tumor Development

November 2011 in “APMIS. Acta pathologica, microbiologica et immunologica Scandinavica./APMIS”

Polyomavirus A2 infection in newborn mice caused hair follicle tumors.

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

54 citations , January 2016 in “Cell reports”

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

research Multiple pigmentierte Basaliome im Capillitium bei Myotonia dystrophia Curschmann-Steinert

18 citations , February 2001 in “Der Hautarzt”

A woman with myotonic dystrophy had multiple skin tumors on her scalp, suggesting a genetic link.

research Differential Expression of Phospho-S6 in Hair Follicle Tumors: Evidence of Mammalian Target of Rapamycin Pathway Activation

4 citations , January 2019 in “Journal of cutaneous pathology”

The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.

research Pilomatricoma on the Abdomen with Overlying Striae Distensae: A Unique Presentation

January 2024 in “Skin”

A rare case of a benign hair follicle tumor with unusual skin changes highlights the need for timely diagnosis to prevent potential cancer.

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