18 citations
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January 2009 in “Experimental Dermatology” The document explored the role of the mammalian target of rapamycin (mTOR) in the formation of hair follicle tumors, which exhibited a wide range of phenotypic and histopathological diversity. While pathways such as sonic hedgehog, nuclear factor kappa‐B, and wingless were well-studied in relation to these tumors, the study highlighted the lesser-known involvement of mTOR. It proposed that mTOR could serve as a connecting element among these various signaling pathways, suggesting a unified model for understanding trichofollicular tumorigenesis.
5 citations
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August 2020 in “Curēus” The document concludes that recent studies help tell apart desmoplastic trichoepitheliomas from other skin tumors, but more research is needed for clear differentiation.
1 citations
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October 2022 in “Veterinary pathology” Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.
4 citations
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January 2019 in “Journal of cutaneous pathology” The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.
1 citations
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September 2011 in “UHOD : Uluslararası hematoloji - onkoloji dergisi” Looking at tissue characteristics isn't reliable for telling apart basal cell carcinoma from certain benign skin tumors.