research Cylindroma as Tumor of Hair Follicle Origin
Cylindromas likely originate from hair follicle stem cells, not sweat glands.
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30 / 1000+ resultsresearch Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin?
This study proposes that mammalian target of rapamycin (mTOR) may connect various signaling pathways in hair follicle tumor formation, offering a potential unified model for understanding these tumors.
research The contribution of stem cells to epidermal and hair follicle tumours in the dog
This study found that K15 is a useful marker for investigating the role of stem cells in canine hair follicle tumours, while nestin is not optimal.
research Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors
This review systematically analyzed literature to differentiate desmoplastic trichoepitheliomas from other cutaneous tumors based on clinical, histopathological, and immunohistochemical features but reports no new clinical results.
research Keratinic amyloid deposition in canine hair follicle tumors
This study found cutaneous keratinic amyloid deposition in dogs and identified cytokeratin 5 as an amyloid precursor protein, revealing new insights into the etiology of cutaneous amyloidosis.
research Hair follicle tumors in dogs: A report of two cases
This report describes cases of trichoblastoma and trichoepithelioma in mixed-breed dogs, highlighting their distinct microscopic characteristics without suggesting broader clinical implications.
research Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.
research Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle
This study found no significant differences in age, sex, or histopathological characteristics for differentiating basal cell carcinoma from benign tumors of cutaneous appendages, complicating diagnosis.
research Evaluation of hair follicles as a surrogate tissue for pharmacodynamics response in xenograft tumors
This research suggests that plucked hair follicles may serve as a reliable surrogate tissue for tumor biopsies in drug development, based on a mouse model linking hair and tumor pharmacodynamic responses.
research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.
research CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice
This study found that CD34 is necessary for TPA-induced activation of hair follicle stem cells and tumor formation in mice, with CD34 knockout mice showing delayed and reduced tumor development compared to wild-types.
research Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle
This study found that chemically induced skin tumors in mice predominantly originated from Lgr6 + and/or Lrig1 + stem cells of the upper hair follicle rather than from other stem cell populations.
research Faculty Opinions recommendation of The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis.
The vitamin D receptor helps control hair growth and may protect against certain skin tumors.
research Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin
This study in ND-GFP transgenic mice found doxorubicin inhibited both tumor angiogenesis and growth, visualized through dual-color fluorescence imaging of nascent blood vessels and melanoma cell lines.
research Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma
The researchers reported that in mice, the type of tumor suppressor deleted along with oncogenic Kras activation in HFSCs influenced the specific squamous cell carcinoma phenotype that developed.
research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch
The study found that over-expressing ornithine decarboxylase in the outer root sheath of the hair follicle in mice increases UVB-induced tumor growth and invasive squamous cell carcinoma compared to inter-follicular epidermal keratinocytes.
research Skin stem cells and tumor growth : functions of collagen XVIII in hair follicle cycling and skin cancer, and Bmx tyrosine kinase in tumor angiogenesis
Collagen XVIII and Bmx tyrosine kinase are important for hair growth and skin cancer development.
research Involvement of hair follicles in skin tumorigenesis, skin homeostasis and wound healing
This review highlights the multifaceted roles of hair follicles in skin health, emphasizing their contribution to skin tumorigenesis, homeostasis, and wound healing, and how dysregulation in associated pathways like Wnt, Hedgehog, and Notch may contribute to skin cancer development.
research 568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation
This study found that removing autophagy in keratinocytes led to increased skin inflammation, higher risk of skin tumors, and early hair follicle activation in mice.
research Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells
This study suggests that hair follicle stem cells have a unique metabolic profile that may play a critical role in their maintenance and response to cancer-related changes, potentially contributing to the "Warburg Effect.
research Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion
In this study, the authors found that targeting mTORC1 with rapamycin inhibited TPA-induced skin tumor promotion by affecting keratinocyte proliferation, including critical stem cell populations in the mouse epidermis.
research CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.
CD10 helps distinguish between basal cell carcinoma and benign hair follicle tumors.
research Seborrheic karatosis, a tumor of the infundibular and isthmus of hair follicles: Identification of hair sheath keratins and histopathological features suggesting hair follicle origin.
This study found that seborrheic keratosis lesions contain high levels of hair sheath keratin, suggesting they may originate from the upper hair follicle.
research Immune Microenvironment of Hair Follicles in Tumor Immunotherapy
This study found that tumor immunotherapy, while effective against solid tumors, can disrupt the immune balance in hair follicles, causing follicular toxicity and alopecia, highlighting the need for targeted interventions to manage these adverse effects.
research The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis
This study observed that the vitamin D receptor is crucial for hair follicle formation and altering tumor development in the Wnt signaling pathway, suggesting therapeutic potential for vitamin D analogues in related tumors.
research 17b-Estradiol is Abundant in Skin and Regulates the Hair Follicle Cycle and Mirex Tumor Promotion
This study found that skin is a significant site for estrogen production in mice, impacting both hair cycle regulation and sensitivity to chemical carcinogenesis.
research Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation
This study found that immunohistochemistry for calretinin may identify certain cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.
research Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation
This study found that phospho-S6 is strongly expressed in malignant hair follicle tumors but only patchily in a minority of benign tumors, indicating a potential marker for distinguishing between the two.