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GlossaryFibrofolliculomas

benign skin tumors originating from hair follicles

Fibrofolliculomas are benign skin tumors that originate from hair follicles. They typically appear as small, flesh-colored or white bumps on the face, neck, or upper torso and are often associated with Birt-Hogg-Dubé syndrome, a genetic condition that can also increase the risk of kidney cancer and lung cysts.

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research Comedonal and Cystic Fibrofolliculomas in Birt-Hogg-Dube Syndrome

33 citations, May 2015 in “JAMA Dermatology”

Early detection of specific skin lesions can help identify Birt-Hogg-Dube syndrome and prevent serious complications.

research Birt-Hogg-Dubé Syndrome: Genetic and Clinical Insights

7 citations, September 2013 in “Familial cancer”

Birt–Hogg–Dubé syndrome is a rare genetic condition causing skin lesions, lung cysts, and a higher chance of kidney cancer.

research Differential Expression of Phospho-S6 in Hair Follicle Tumors: Evidence of Mammalian Target of Rapamycin Pathway Activation

4 citations, January 2019 in “Journal of cutaneous pathology”

The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.

research What’s New in Birt–Hogg–Dubé Syndrome?

December 2012 in “Expert review of dermatology”

New findings suggest the protein linked to Birt–Hogg–Dubé syndrome is important in cell signaling and could affect treatment understanding.

research The Case: Bilateral Kidney Tumors and Lung Cysts

January 2013 in “Kidney international”

A man with kidney tumors and lung cysts was diagnosed with Birt–Hogg–Dubé syndrome and treated successfully, with genetic testing confirming the diagnosis.

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