Immune-Mediated Skin Reactions Induced by Recombinant Antibodies and Other TNF-Alpha Inhibitors
February 2018
in “
InTech eBooks
”
TLDR TNF-alpha inhibitors can cause various immune-related skin issues.
Biologic agents inhibiting TNF-alpha have revolutionized treatment for chronic inflammatory diseases but have introduced new immune-mediated adverse effects. These effects, including psoriasis, lupus-like syndrome, sarcoidosis, alopecia areata, vasculitis, and lichenoid reactions, arise from disrupted cytokine cascades in genetically predisposed individuals. Theories suggest cross-reactions and cytokine dysregulation, particularly involving IL-17 and INF-alpha. Paradoxical reactions, such as paradoxical psoriasis, occur when the treatment induces the very conditions it aims to treat. Less common reactions include pyoderma gangrenosum and morphea.
