TLDR TNF-alpha inhibitors can cause various immune-related skin issues.
Biologic agents inhibiting TNF-alpha have revolutionized treatment for chronic inflammatory diseases but have introduced new immune-mediated adverse effects. These effects, including psoriasis, lupus-like syndrome, sarcoidosis, alopecia areata, vasculitis, and lichenoid reactions, arise from disrupted cytokine cascades in genetically predisposed individuals. Theories suggest cross-reactions and cytokine dysregulation, particularly involving IL-17 and INF-alpha. Paradoxical reactions, such as paradoxical psoriasis, occur when the treatment induces the very conditions it aims to treat. Less common reactions include pyoderma gangrenosum and morphea.
15 citations,
March 2021 in “Journal of clinical medicine” Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.
35 citations,
October 2012 in “Dermatologic Clinics” Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.
70 citations,
October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.
2 citations,
January 2014 in “Springer eBooks” The book details skin conditions in older adults, their link to mental health, cancer treatment importance, hair loss remedies, and managing autoimmune and itchy skin.
January 2017 in “Springer eBooks” The document concludes that Cutaneous Lupus Erythematosus has different forms, is influenced by genetic and environmental factors, and can be treated with various medications, but more targeted therapies are needed.
