Immune-Mediated Skin Reactions Induced by Recombinant Antibodies and Other TNF-Alpha Inhibitors

February 2018 in “ InTech eBooks ”

Karolína Vorčáková, Péc J, Tatiana Péčová, Martinásková Klára

TNF-alpha inhibitors psoriasis lupus-like syndrome sarcoidosis alopecia areata vasculitis lichenoid reactions cytokine cascades IL-17 INF-alpha paradoxical psoriasis pyoderma gangrenosum morphea

TLDR TNF-alpha inhibitors can cause various immune-related skin issues.

Biologic agents inhibiting TNF-alpha have revolutionized treatment for chronic inflammatory diseases but have introduced new immune-mediated adverse effects. These effects, including psoriasis, lupus-like syndrome, sarcoidosis, alopecia areata, vasculitis, and lichenoid reactions, arise from disrupted cytokine cascades in genetically predisposed individuals. Theories suggest cross-reactions and cytokine dysregulation, particularly involving IL-17 and INF-alpha. Paradoxical reactions, such as paradoxical psoriasis, occur when the treatment induces the very conditions it aims to treat. Less common reactions include pyoderma gangrenosum and morphea.

View this study on api.intechopen.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 8 results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 445 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 8 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 7 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Dutasteride actually has different half lives depending on dose

in Research/Science 37 upvotes 3 weeks ago

Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

Similar Research

5 / 1000+ results

research Cutaneous Manifestations in Biologically Treated Inflammatory Bowel Disease Patients: A Narrative Review

15 citations, March 2021 in “Journal of clinical medicine”

Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.

research Autoimmune Disease and Hair Loss

35 citations, October 2012 in “Dermatologic Clinics”

Autoimmune diseases can cause hair loss, and early treatment is important to prevent permanent damage.

research Cutaneous Lupus Erythematosus: Overview and Treatment

January 2017 in “Springer eBooks”

The document concludes that Cutaneous Lupus Erythematosus has different forms, is influenced by genetic and environmental factors, and can be treated with various medications, but more targeted therapies are needed.

research Off-Label Uses of Retinoids in Dermatology

6 citations, September 2012 in “Our Dermatology Online”

Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.

research Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions

January 2018 in “Springer eBooks”

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.