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GlossaryPyoderma Gangrenosum

rare skin condition causing painful, rapidly progressing ulcers

Pyoderma Gangrenosum (PG) is a rare, inflammatory skin condition characterized by painful ulcers, typically starting as small pustules or nodules that rapidly progress to larger, necrotic lesions. It is often associated with systemic diseases such as inflammatory bowel disease, rheumatoid arthritis, and hematologic disorders, and its exact cause is unknown, though it is believed to involve immune system dysfunction. Treatment usually involves immunosuppressive medications to control inflammation and promote healing.

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research Superficial Granulomatous Pyoderma: A Localized Vegetative Form of Pyoderma Gangrenosum

152 citations, March 1988 in “Journal of The American Academy of Dermatology”

Superficial granulomatous pyoderma is a unique, mild form of skin disease that often heals without strong medication and responds well to milder treatments.

Paradoxical Skin Reaction to Certolizumab: Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis - Case Report with Literature Review

research Paradoxical Skin Reaction to Certolizumab: Overlap of Pyoderma Gangrenosum and Psoriasis in a Young Woman Treated for Ankylosing Spondylitis - Case Report with Literature Review

12 citations, May 2020 in “Dermatology and therapy”

A young woman had a rare skin reaction to a medication for her joint disease, and a combination therapy improved her condition.

Pyoderma Gangrenosum With Neurofibromatosis: Understanding A Possible Relationship And Identifying Risk With Immunosuppressants

research Pyoderma Gangrenosum With Neurofibromatosis: Understanding A Possible Relationship And Identifying Risk With Immunosuppressants

October 2023 in “Nepal journal of dermatology, venereology & leprology”

The document suggests doctors should watch for bone marrow suppression and severe hair loss in patients treated with Azathioprine.

research Bullous Pyoderma Gangrenosum Occurring on a Cesarean Section Scar

1 citations, January 2022 in “Indian Journal of Dermatology”

Bullous pyoderma gangrenosum can develop on cesarean scars and may require steroids for treatment.

Tofacitinib for the Treatment of Three Immune-Mediated Conditions in One Patient: Ulcerative Colitis, Pyoderma Gangrenosum, and Alopecia Areata

research Tofacitinib for the Treatment of Three Immune-Mediated Conditions in One Patient: Ulcerative Colitis, Pyoderma Gangrenosum, and Alopecia Areata

5 citations, January 2021 in “Inflammatory Bowel Diseases”

Tofacitinib improved ulcerative colitis, skin ulcers, and hair loss in a patient who didn't respond well to other treatments.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.