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    GlossaryPAPA Syndrome

    rare genetic disorder causing arthritis, skin ulcers, and severe acne

    PAPA Syndrome, or Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome, is a rare genetic disorder characterized by recurrent episodes of joint inflammation (arthritis), painful skin ulcers (pyoderma gangrenosum), and severe acne. It is caused by mutations in the PSTPIP1 gene, which affects the immune system and leads to excessive inflammation.

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      Acne and Systemic Disease

      research Acne and Systemic Disease

      76 citations , November 2009 in “Medical Clinics of North America”
      Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.
      Acne as a Chronic Systemic Disease

      research Acne as a Chronic Systemic Disease

      71 citations , November 2013 in “Clinics in Dermatology”
      Acne is a chronic disease linked to various systemic conditions and has significant psychological and social effects.
      Difficult and Rare Forms of Acne

      research Difficult and Rare Forms of Acne

      18 citations , October 2016 in “Clinics in Dermatology”
      The document talks about hard-to-treat and rare acne types, their connection with other health issues, the importance of correct diagnosis, and the challenges in managing them.

      research Commentary 2

      January 2005 in “Experimental Dermatology”
      Genetic factors play a major role in acne.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I just made my own PRP - DIY PRP

      in Research/Science  552 upvotes 2 years ago
      The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.

      community Dut kept my hair but nuked my peepee

      in Finasteride/Dutasteride  100 upvotes 1 week ago
      A user experienced hair retention but sexual side effects after using dutasteride for a year. Others shared similar experiences with finasteride and dutasteride, suggesting consulting a doctor for persistent issues.

      community 3,5 months of only topical minoxidil

      in Minoxidil  774 upvotes 4 weeks ago
      A 24-year-old reported new hair growth on temples after 3.5 months of using topical minoxidil without shedding. They plan to add finasteride to maintain progress, as minoxidil alone may not be enough long-term.

      community 10 Days Post-Op: Hair Transplant Results and Experience

      in Progress Pictures  504 upvotes 1 year ago
      A user shared their positive experience with a hair transplant at Dr. Resul Yaman Hair Clinic in Istanbul, including before and after photos. They are considering taking oral Minoxidil post-operation but are avoiding Finasteride due to side effects.
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