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    Glossary PAPA Syndrome

    rare genetic disorder causing arthritis, skin ulcers, and severe acne

    PAPA Syndrome, or Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome, is a rare genetic disorder characterized by recurrent episodes of joint inflammation (arthritis), painful skin ulcers (pyoderma gangrenosum), and severe acne. It is caused by mutations in the PSTPIP1 gene, which affects the immune system and leads to excessive inflammation.

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    5 / 298 results

      research Acne and Systemic Disease

      76 citations , November 2009 in “Medical Clinics of North America”
      This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.

      research Acne as a chronic systemic disease

      71 citations , November 2013 in “Clinics in Dermatology”
      This review discusses the chronic nature of acne and its association with various systemic diseases, but reports no new clinical findings, highlighting the need for further study on its nutritional or genetic links.

      research Difficult and rare forms of acne

      18 citations , October 2016 in “Clinics in Dermatology”
      This review discusses the challenges and complexities in diagnosing and managing acne and reports no new clinical findings; it emphasizes the need for careful evaluation to distinguish difficult acne from similar conditions.

      research Commentary 2

      January 2005 in “Experimental Dermatology”
      This abstract reviews recent findings on genetic factors in acne, highlighting the potential of genetic studies to advance understanding of its pathogenesis, but reports no new clinical results.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 2 years ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
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