Commentary 2

The document discussed the potential of genetic studies in understanding acne, highlighting several genetic syndromes and studies. Apert syndrome, caused by mutations in FGFR2, was associated with extensive acne and other symptoms, suggesting FGFR2 as a candidate for acne research. PAPA syndrome, linked to mutations in CD2BP1, involved severe cystic acne and indicated the need for further study of its inflammatory system. The XYY phenotype was mentioned in relation to nodulocystic acne. A twin study involving over 1500 pairs found that 81% of acne variance was due to genetic factors, emphasizing the importance of genetic research in acne.