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Glossary Apert Syndrome

genetic disorder causing premature skull bone fusion and syndactyly

Apert Syndrome is a genetic disorder characterized by the premature fusion of certain skull bones, leading to a distorted shape of the head and face. This condition often results in syndactyly (webbing of fingers and toes) and can be associated with other issues such as hearing loss, vision problems, and intellectual disability. It is caused by mutations in the FGFR2 gene and is typically diagnosed through clinical evaluation and genetic testing.

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research Pilomatricoma in Syndromic Contexts: A Literature Review and a Report of a Case in Apert Syndrome

August 2025 in “Dermatopathology”

This study identified 96 cases of pilomatricomas linked to genetic syndromes, including a novel association with Apert syndrome, highlighting that these tumors often manifest as the first indication of underlying conditions in pediatric patients.

research Acne-associated syndromes: models for better understanding of acne pathogenesis

99 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”

This article discusses the association of acne with various systemic diseases, emphasizing the role of androgen steroids, insulin resistance, and inflammation in acne pathogenesis, but it reports no new clinical results.

research Acne Syndromes and Mosaicism

1 citations , November 2021 in “Biomedicines”

This review elaborates on the concept of cutaneous mosaicism and its link to acneiform conditions, but it reports no new clinical results.

research Ectrodactyly, Soft‐Tissue Syndactyly, and Nodulocystic Acne: Coincidence or Association?

6 citations , January 1997 in “Pediatric dermatology”

This case report highlights a 21-year-old man with severe nodulocystic acne resistant to conventional treatments, who showed moderate improvement with isotretinoin, and discusses its potential link to congenital digital abnormalities and Apert syndrome.

research Acne and Systemic Diseases

1 citations , November 2015 in “European medical journal”

This article reviews the complex role of various biological, genetic, and environmental factors in acne pathogenesis and notes no new clinical results.

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community Petition Alert: Let's Get PP405 Phase 3 Trials in Germany by 2026!

55 upvotes 1 year ago

A user is advocating for Phase 3 trials of the hair loss treatment PP405 to be conducted in Germany, citing benefits like a diverse patient base and faster access for European patients. Despite skepticism about the petition's influence, the user believes it can demonstrate significant interest and potentially influence strategic decisions.

community Both photos are 10 months apart

in Progress Pictures 193 upvotes 8 months ago

The user experienced hair regrowth using finasteride and minoxidil over 8 months, with noticeable improvements starting in June. They reported side effects like erectile dysfunction and flakes but continued treatment as the effects were not permanent.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community I can't take it anymore, thinking about the worst

in Finasteride/Dutasteride 13 upvotes 1 year ago

The individual is struggling with hair loss and depression, having tried treatments like Finasteride, Dutasteride, and Minoxidil, but faced side effects and limited success. They are considering a hair transplant and other options while dealing with personal challenges, including knee injuries and weight issues, and are encouraged by others to focus on self-improvement and acceptance.

community Sometimes the hair loss was in our control the whole time

833 upvotes 1 year ago

The conversation discusses hair loss and the potential impact of diet and lifestyle changes, particularly increased protein intake, on hair health. The original poster shared their experience of improved hair appearance after weight loss and dietary changes, despite skepticism from others about lighting differences in photos and the effectiveness of diet alone without finasteride or minoxidil.

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