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GlossaryIFAP Syndrome

rare genetic disorder causing scaly skin, no hair, light sensitivity

IFAP Syndrome, also known as Ichthyosis Follicularis Atrichia Photophobia Syndrome, is a rare genetic disorder characterized by three main features: ichthyosis follicularis (a skin condition causing dry, scaly skin), atrichia (absence of hair), and photophobia (sensitivity to light). It is typically inherited in an X-linked recessive pattern, meaning it primarily affects males, and is caused by mutations in the MBTPS2 gene.

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research Ichthyosis Follicularis with Alopecia and Photophobia Syndrome (IFAP): A Case Report and Review of the Literature

September 2020

The document describes a rare case of IFAP syndrome, a genetic condition with symptoms of hair loss, light sensitivity, and scaly skin.

research Two Novel MBTPS2 Missense Mutations Impairing S2P Proteolytic Activity Lead to IFAP Syndrome With New Phenotypic Anomalies

October 2023 in “Journal of dermatological science”

New mutations in MBTPS2 reduce its function and cause IFAP syndrome with unusual symptoms.

research A Brazilian Case of IFAP Syndrome With Severe Congenital Ichthyosis and Limb Malformations Caused by a Rare Variant in MBTPS2

January 2023 in “Revista Paulista de Pediatria”

A Brazilian male with IFAP syndrome has a unique genetic variant causing his condition.

research Ichthyosis Follicularis With Alopecia And Photophobia Syndrome With Coexisting Palmoplantar Keratoderma Treated With Acitretin

1 citations, November 2022 in “International journal of trichology”

A girl with a rare skin condition improved after one month of treatment with acitretin.

research Inherited Ichthyosis: Syndromic Forms

47 citations, March 2016 in “Journal of dermatology”

Understanding the genetics of rare inherited ichthyosis syndromes is key for better treatments and genetic counseling.

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community i think i have finally found my retrogade alopecia triggers

in Finasteride/Dutasteride 9 upvotes 7 months ago

The user experienced severe scalp itching and hair loss while on dutasteride, which they linked to caffeine and masturbation. They plan to cut out both to see if their hair density improves.

community If you feel deep about your hair loss, read this, this is my experience & things I want to discuss!

in Research/Science 6 upvotes 4 years ago

The user experienced hair loss from age 16 to 24 and tried various treatments. Effective treatments included Finasteride, Minoxidil, and hair transplants, while thickening shampoos, biotin, laser hair therapy, and excessive exercise were ineffective.

community Completely defeated after trying so hard with topical finasteride.

in Finasteride/Dutasteride 24 upvotes 2 years ago

A user who has tried multiple treatments for hair loss, including oral and topical finasteride and liposomal finasteride, but experienced severe side effects in each case; the user is considering trying RU58841 or aromatise inhibitors as alternatives.

community [23M] 1.5 year update. Minoxidil+derma roller+hair oil

in Progress Pictures 13 upvotes 8 months ago

A user shared their 1.5-year experience using Minoxidil, a derma roller, and hair oil for hair loss, noting significant improvements in hair health and density. They also emphasized the importance of a healthier lifestyle and the positive impact of using a product combining Minoxidil with plant extracts.

community Thoughts on Finasteride and Sexual Side Effects

in Finasteride 51 upvotes 5 years ago

A user discusses starting finasteride for hair loss despite concerns about potential sexual side effects, emphasizing the psychological factors involved. Other users share mixed experiences, with some reporting no side effects and others experiencing issues.

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