An Atypical Female Case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) Syndrome with Severe Lower Limb Contractures Requiring Orthopedic Surgery

December 2025 in “ Clinical Cosmetic and Investigational Dermatology ”

Alireza Ghaznavi, Hoda Borooghani, Alireza Pahlevan Sabagh, Taghi Aghajanlou

Ichthyosis Follicularis Alopecia IFAP syndrome

TLDR Early diagnosis and multidisciplinary care, including orthopedic surgery, can prevent long-term disability in IFAP syndrome.

This document discusses a unique case of a female with Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome, who presented atypically without photophobia but with severe lower limb contractures necessitating orthopedic surgery. The case highlights the importance of early diagnosis and a multidisciplinary approach, including orthopedic care, to prevent long-term disability and improve the patient's quality of life.

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The document describes a rare case of IFAP syndrome, a genetic condition with symptoms of hair loss, light sensitivity, and scaly skin.

An Atypical Female Case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) Syndrome with Severe Lower Limb Contractures Requiring Orthopedic Surgery

Research cited in this study

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