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An essential vasodilator with some anti-androgenic effects, has excellent safety record
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research The Expression of Vitamin D-Upregulated Protein 1 in Skin and Its Interaction with Sciellin in Cultured Keratinocytes
VDUP1 is found in skin and hair follicles, interacts with sciellin, and may help regulate skin cell differentiation.
research Diagnostic Challenge: Loose Anagen Hair Syndrome
The study concludes that Loose Anagen Hair Syndrome is a benign condition that usually improves with age but can be hard to diagnose and stressful for the family.
research Clinical Significance of Dense Fine Speckled Pattern in Anti-nuclear Antibody Test Using Indirect Immunofluorescence Method
The dense fine speckled pattern in ANA tests is common in autoimmune diseases, challenging previous beliefs that it was unrelated.
research Skin Biopsy
Correct skin biopsy techniques are crucial to avoid misdiagnosis of skin diseases.
research Identification of Human Hair Follicle Antigens Targeted in the Presumptive Autoimmune Hair Follicle Disorder Alopecia Areata and Their Potential Functional Relevance In Vitro: Methods Development for Isolation and Identification of Alopecia Areata-Relevant Human Hair Follicle Antigens Using a Proteomics Approach and Their Functional Assessment Using an Ex Vivo Hair Follicle Organ Culture Model
Alopecia areata may be caused by antibodies targeting specific hair follicle proteins, hindering hair growth.
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5 / 86 resultscommunity Anyone tried Resveratrol, NMN, or Quercetin?
Resveratrol may impair exercise benefits and isn't popular for heart health. Quercetin might reduce hair greying, while NMN is relatively new with limited information.
community Anyone know by what percentage Pyrilutamide or Ru decrease your androgens?
Pyrilutamide and RU58841 are androgen receptor antagonists that block receptors without significantly reducing testosterone or DHT levels. Any indirect effect on androgen levels is likely negligible.
community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?
Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.
community Pyrilutamide ,the molecule’s true nature
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Typical-Promise-3001
in Research
302 upvotes
1 year ago Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.
community 2 months on topical Finasteride, Minoxidil.
The user started using 0.05% topical finasteride and minoxidil for hair loss treatment on December 15, also incorporating dermarolling and rosemary oil, and is satisfied with the visible improvement in their receding hairline. Another user inquired about where to obtain topical finasteride.