Clinical Significance of Dense Fine Speckled Pattern in Anti-nuclear Antibody Test Using Indirect Immunofluorescence Method

April 2009 in “ Annals of laboratory medicine ”

So Young Kang, Wooin Lee

dense fine speckled pattern anti-nuclear antibody indirect immunofluorescence HEp-2 cells autoimmune diseases seborrheic dermatitis herpes zoster rheumatoid arthritis systemic lupus erythematosus Sjogren syndrome anti-DFS70 antibodies ANA DFS pattern SLE RA

TLDR The dense fine speckled pattern in ANA tests is common in autoimmune diseases, challenging previous beliefs that it was unrelated.

Between May 2007 and February 2008, a study involving 2,654 patients who underwent ANA testing using indirect immunofluorescence on HEp-2 cells found that 13.3% (352 patients) were ANA positive, and among these, 28.7% (101 patients) exhibited a dense fine speckled (DFS) pattern. The DFS pattern was more prevalent in patients with autoimmune diseases such as seborrheic dermatitis (14.3%), herpes zoster (11.1%), rheumatoid arthritis (16.9%), systemic lupus erythematosus (15.4%), and Sjogren syndrome (14.3%). These results contradicted earlier beliefs that the DFS pattern was unrelated to autoimmune diseases. The study concluded that the DFS pattern is a common finding in ANA tests, particularly in autoimmune diseases, and suggested the need for further research, including tests for anti-DFS70 antibodies, to better understand the relationship between the DFS pattern and specific diseases.

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