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Glossary Rheumatoid Arthritis

chronic autoimmune disorder causing joint inflammation and pain

Rheumatoid Arthritis (RA) is a chronic autoimmune disorder where the body's immune system mistakenly attacks the joints, leading to inflammation, pain, and swelling. Over time, this can result in joint damage, deformities, and loss of function. RA can also affect other organs and systems in the body, making it a systemic disease.

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Research

5 / 1000+ results

research Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients

31 citations , February 2014 in “Inflammation Research”

This study found that reduced expression of CD200R1 on monocyte-derived macrophages in rheumatoid arthritis patients was significantly associated with higher disease severity and an imbalance in Th17/Treg cells.

research Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis

20 citations , June 2024 in “Journal of Autoimmunity”

This study found that in rheumatoid arthritis patients, inflammatory macrophages activate steroid metabolism to increase glucocorticoid and androgen production, which helps suppress inflammation and attenuate hyperproliferation in synovial fibroblasts, with notable disturbances seen in postmenopausal women due to diminished inactive steroid precursors.

research Successful hair regrowth in an acute diffuse form of alopecia areata during oral tacrolimus treatment in a patient with rheumatoid arthritis

8 citations , August 2016 in “Journal of the European Academy of Dermatology and Venereology”

Oral tacrolimus helped a rheumatoid arthritis patient regrow hair lost due to alopecia areata.

research Alopecia universalis unter Adalimumabtherapie bei einer Patientin mit rheumatoider Arthritis

6 citations , May 2018 in “Zeitschrift für Rheumatologie”

This case report describes a 56-year-old woman with rheumatoid arthritis who developed alopecia universalis during treatment with the TNF inhibitor adalimumab, with no hair regrowth after stopping the medication.

research Alopecia areata secondary to the use of leflunomide in patients with rheumatoid arthritis: a case report and literature review

6 citations , December 2015 in “Medwave”

This article presents a case of alopecia universalis linked to leflunomide use and reviews its application in rheumatoid arthritis treatment, highlighting potential adverse effects.

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Community Join

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community Rejected for the 2nd time for the VDPHL01 Clinical Trials (believe it or not!)

in Chat 12 upvotes 1 year ago

The user was rejected from participating in a clinical trial for an extended-release oral Minoxidil due to having rheumatoid arthritis, despite initially being accepted. They had stopped using Dutasteride and Minoxidil to qualify but continued using other treatments like RU58841 and red light therapy.

community Drug restored full hair in 23% and over 80% of hair in 55% in 6 months

240 upvotes 3 weeks ago

An arthritis drug restored significant hair in people with alopecia areata, but it is not effective for male pattern baldness. The drug, Upadacitinib, has serious side effects and is expensive.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 1 year ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community No idea what's causing my hair thinning

in Chat 2 upvotes 1 year ago

The user is experiencing diffuse hair thinning despite using finasteride and oral minoxidil, with no hairline recession or bald spots. Suggestions include checking for telogen effluvium, considering a JAK inhibitor for potential autoimmune issues, and conducting further tests to rule out other causes.

community Creatine is the opposite of minoxidil !

324 upvotes 11 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

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Learn

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learn Tofacitinib

JAK inhibitor pill, an immune-system drug

What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.

learn Baricitinib

JAK inhibitor pill used for severe alopecia areata

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