Overview of Common, Rare, and Atypical Manifestations of Cutaneous Lupus Erythematosus and Histopathological Correlates

    August 2010 in “ Lupus ”
    Gerlinde Obermoser, RD Sontheimer, Bernhard Zelger
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    TLDR The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.
    The document from 2010 provides a comprehensive review of cutaneous lupus erythematosus (CLE), detailing its various forms such as acute, subacute, and chronic CLE, as well as rare and atypical manifestations like lupus tumidus, lupus profundus, and others. It discusses the histopathological features essential for diagnosis, including interface changes and lymphocytic infiltrates, and the role of interferon-a-inducible proteins in CLE. The review also notes the importance of recognizing CLE as a systemic disease with potential internal organ involvement. It highlights the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) for assessing disease activity and damage, and the variable progression of CLE to systemic lupus erythematosus (SLE), with a study indicating a progression rate of one in eight CLE patients over 20 years. The document underscores the critical role of dermatologists in early diagnosis and treatment adjustment for lupus skin disease to manage systemic symptoms effectively.
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