Clinico-Pathological Profile of Cutaneous Lupus Erythematosus Patients: A Report from a Tertiary Care Center of Chattogram

November 2021 in “ Chattagram Maa-O-Shishu Hospital Medical College Journal ”

Mohammad Rafiqul Mowla, Deva Pratim Barua, Shakila Zaman, Mohammad Ismail Hossain Chowdhury, Papri Dutta, Md Wazed Ali Mridha

Cutaneous Lupus Erythematosus Chronic Cutaneous Lupus Erythematosus Acute Cutaneous Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus photosensitivity discoid rash nonscarring alopecia Antinuclear Antibody erythrocyte sedimentation rate Systemic Lupus Erythematosus CLE CCLE ANA SLE

TLDR Most patients with Cutaneous Lupus Erythematosus are young females, and dermatologists play a key role in diagnosis.

This study describes the clinico-pathological profile of 218 patients with Cutaneous Lupus Erythematosus (CLE) from Chittagong Medical College Hospital. The majority were females (86%) with a mean age of 28 years. Chronic Cutaneous Lupus Erythematosus (CCLE) was the most common subtype (71%), followed by Acute (21%) and Subacute (8%) forms. Photosensitivity (91%) and discoid rash (71%) were the most frequent skin manifestations. Nonscarring alopecia was the most common nonspecific lesion (56%). Antinuclear Antibody (ANA) was the most prevalent autoantibody (61%). Hematological abnormalities were common, with erythrocyte sedimentation rate being the most frequent (73.85%). The study highlights the importance of dermatologists in diagnosing and classifying CLE due to its varied clinical presentations and the potential overlap with Systemic Lupus Erythematosus (SLE).

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