Clinico-Pathological Profile of Cutaneous Lupus Erythematosus Patients: A Report from a Tertiary Care Center of Chattogram

November 2021 in “ Chattagram Maa-O-Shishu Hospital Medical College Journal ”

Mohammad Rafiqul Mowla, Deva Pratim Barua, Shakila Zaman, Mohammad Ismail Hossain Chowdhury, Papri Dutta, Md Wazed Ali Mridha

Cutaneous Lupus Erythematosus Chronic Cutaneous Lupus Erythematosus Acute Cutaneous Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus photosensitivity discoid rash nonscarring alopecia Antinuclear Antibody erythrocyte sedimentation rate Systemic Lupus Erythematosus CLE CCLE ANA SLE

TLDR Most patients with Cutaneous Lupus Erythematosus are young females, and dermatologists play a key role in diagnosis.

This study describes the clinico-pathological profile of 218 patients with Cutaneous Lupus Erythematosus (CLE) from Chittagong Medical College Hospital. The majority were females (86%) with a mean age of 28 years. Chronic Cutaneous Lupus Erythematosus (CCLE) was the most common subtype (71%), followed by Acute (21%) and Subacute (8%) forms. Photosensitivity (91%) and discoid rash (71%) were the most frequent skin manifestations. Nonscarring alopecia was the most common nonspecific lesion (56%). Antinuclear Antibody (ANA) was the most prevalent autoantibody (61%). Hematological abnormalities were common, with erythrocyte sedimentation rate being the most frequent (73.85%). The study highlights the importance of dermatologists in diagnosing and classifying CLE due to its varied clinical presentations and the potential overlap with Systemic Lupus Erythematosus (SLE).

View this study on banglajol.info →

Discuss this study in the Community →

Related Community Posts Join

6 / 12 results

community How do you use rosemary oil and peppermint oil?

in Question 6 upvotes 4 years ago

Rosemary oil and peppermint oil may promote hair growth and increase cutaneous blood flow, showing promise as treatments for androgenetic alopecia. Minoxidil 2% is also used for treating hair loss.

community Scientific evidence for Peppermint & Rosemary oils + My Experience

in Research/Science 114 upvotes 2 years ago

Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

community high bloodpressure and crown thinning in early 20s

in Is this regrowth? 9 upvotes 6 months ago

A user with kidney disease and high blood pressure experienced hair thinning, especially around the vertex. They are currently using finasteride and oral minoxidil but are considering whether to resume blood pressure medication despite managing symptoms with diet and exercise.

community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

in Research/Science 112 upvotes 1 year ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Why is everyone not directly advised Dutasteride?

in Finasteride/Dutasteride 167 upvotes 2 months ago

Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

Related Research

2 / 2 results

research Bullous Lesions in Patients with Cutaneous Lupus Erythematosus: A Clinicopathologic Study

1 citations, January 2021 in “Journal of the American Academy of Dermatology”

Careful histologic examination is crucial to differentiate types of bullous lesions in cutaneous lupus erythematosus.

$Management of Refractory Skin Disease in Patients with Lupus Erythematosus$

research Management of Refractory Skin Disease in Patients with Lupus Erythematosus

30 citations, September 2005 in “Best Practice & Research Clinical Rheumatology”

The document concludes that treating tough skin disease in lupus involves sun protection, steroids, antimalarials, and various other therapies chosen based on individual risks and benefits.