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GlossarySubacute Cutaneous Lupus Erythematosus

form of lupus causing red, scaly skin lesions

Subacute Cutaneous Lupus Erythematosus (SCLE) is a form of lupus that primarily affects the skin, causing red, scaly patches or ring-shaped lesions, often on sun-exposed areas like the face, neck, and arms. Unlike systemic lupus erythematosus (SLE), SCLE typically does not involve major internal organs, but it can be associated with mild systemic symptoms and is often triggered or worsened by sun exposure.

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research Subacute Cutaneous Lupus Erythematosus Presenting as Erythroderma

41 citations, August 1988 in “Journal of The American Academy of Dermatology”

A woman with subacute cutaneous lupus erythematosus had widespread skin symptoms triggered by medication and sunlight, which improved with specific treatments.

research Exacerbation of Subacute Cutaneous Lupus Erythematosus Following Vaccination with BNT162b2 mRNA Vaccine

33 citations, June 2021 in “Dermatologic Therapy”

COVID-19 vaccines can trigger autoimmune flares but are still beneficial for patients with autoimmune conditions.

research Clinical Manifestations of Cutaneous Lupus Erythematosus

148 citations, February 2005 in “Autoimmunity Reviews”

Most people with systemic lupus erythematosus have skin problems, and skin symptoms are often the first sign of the disease.

research The Spectrum of Cutaneous Manifestations in Lupus Erythematosus: The Italian Experience

132 citations, July 2000 in “Lupus”

In Italian patients with lupus, the most common skin issue was chronic cutaneous lupus, especially discoid lesions, and nonspecific skin problems occurred in about a third of those with systemic lupus, mainly during active disease.

research Cutaneous Lupus Erythematosus: A Comprehensive Review

74 citations, March 2001 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that skin biopsies, genetic and environmental factors, and specific treatments are important in managing cutaneous lupus erythematosus.

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