Management of Refractory Skin Disease in Patients with Lupus Erythematosus

    September 2005 in “ Best Practice & Research Clinical Rheumatology ”
    Jeffrey P. Callen
    Image of study
    TLDR The document concludes that treating tough skin disease in lupus involves sun protection, steroids, antimalarials, and various other therapies chosen based on individual risks and benefits.
    The 2005 document reviews the management of refractory skin disease in lupus erythematosus patients, particularly chronic and subacute forms. It emphasizes the importance of sun protection due to high photosensitivity in these patients and outlines various treatments, including topical therapies like corticosteroids and retinoids, and systemic therapies such as antimalarials, which are less effective in smokers. Sulfasalazine was successful in 8 out of 11 patients, auranofin showed complete remission in 15% of patients, and thalidomide was highly effective but had serious side effects. Phenytoin was excellent in 90% of 93 patients, and immunosuppressives like azathioprine, methotrexate, and mycophenolate mofetil were beneficial for severe cases. Biologic agents and cytokine therapy showed promise but lacked long-term safety data. The document concludes that standard therapy includes sunscreens, protective clothing, topical and intralesional corticosteroids, and oral antimalarials, with alternative therapies being a personal choice after risk-benefit discussions. Specific study participant numbers for each treatment are not provided.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 58 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community "DHT Itch" and onset Seborrheic Dermatitis

      in Research/Science  76 upvotes 1 year ago
      The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

      community Seborrheic dermatitis - can it cause long-term shedding (or telogen effluvium)?

      in Advice  6 upvotes 4 years ago
      A user is experiencing significant hair loss and scalp issues despite using Minoxidil, finasteride, and RU58841 since 2017. They switched to oral Minoxidil and are now on isotretinoin and topical corticosteroids for seborrheic dermatitis but continue to lose hair and seek advice on whether inflammation or treatment changes are the cause.

      community 17M biotin and minoxidil hair regrowth progress

      in Progress Pictures  83 upvotes 1 year ago
      A user's hair regrowth journey using biotin and minoxidil after initial treatments with Nizoral shampoo and Ketoconazole serum didn't work. The comments suggest the hair loss might not be male pattern baldness (MPB), but possibly Alopecia Areata, an autoimmune disorder, and recommend getting a second opinion and considering other treatments like corticosteroids.

    Related Research

    2 / 2 results