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GlossaryThalidomide

medication causing birth defects, now used for specific conditions

Thalidomide is a medication that was originally developed in the late 1950s as a sedative and treatment for morning sickness in pregnant women. However, it was later found to cause severe birth defects, leading to its withdrawal from the market. Today, thalidomide is used under strict regulations to treat certain conditions like multiple myeloma and complications of leprosy, due to its anti-inflammatory and immunomodulatory properties.

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research Lupus Erythematosus: Systemic and Cutaneous Manifestations

144 citations, September 2006 in “Clinics in Dermatology”

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

$Management of Refractory Skin Disease in Patients with Lupus Erythematosus$

research Management of Refractory Skin Disease in Patients with Lupus Erythematosus

30 citations, September 2005 in “Best Practice & Research Clinical Rheumatology”

The document concludes that treating tough skin disease in lupus involves sun protection, steroids, antimalarials, and various other therapies chosen based on individual risks and benefits.

research Cutaneous Lupus Erythematosus: A Comprehensive Review

74 citations, March 2001 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that skin biopsies, genetic and environmental factors, and specific treatments are important in managing cutaneous lupus erythematosus.

research Decades of Progressive Red and Yellow Nodules

November 2011

A 72-year-old man was diagnosed with a rare skin form of Rosai-Dorfman disease after years of misdiagnosis.

research Cutaneous Manifestations of Lupus Erythematosus

January 2012 in “Springer eBooks”

Lupus can cause different skin problems, and treatments like quitting smoking and using certain creams or medicines can help.

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community Pyrilutamide vs enzalutamide. Same thing?( Especially for biochemists, farmacologists)

in Research/Science 17 upvotes 2 years ago

Researching whether pyri and enza, which are stereoisomers of each other, share the same features related to CNS penetration/GABA Inhibition; safety and efficacy when used topically at 0.5-1%; and cost comparison between the two treatments.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 151 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.