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GlossaryThalidomide

medication causing birth defects, now used for specific conditions

Thalidomide is a medication that was originally developed in the late 1950s as a sedative and treatment for morning sickness in pregnant women. However, it was later found to cause severe birth defects, leading to its withdrawal from the market. Today, thalidomide is used under strict regulations to treat certain conditions like multiple myeloma and complications of leprosy, due to its anti-inflammatory and immunomodulatory properties.

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research Lichen Planopilaris Treated With Thalidomide

37 citations, December 2001 in “Journal of the American Academy of Dermatology”

Thalidomide significantly improved hair regrowth in a woman with lichen planopilaris.

research Selective Sensing of Darolutamide and Thalidomide in Pharmaceutical Preparations and in Spiked Biofluids

2 citations, November 2022 in “Biosensors”

A new, efficient method has been developed to detect darolutamide and thalidomide, drugs used for certain hair loss and prostate cancer treatments, in pharmaceuticals and body fluids.

$Characteristics and Alternative Treatment Outcomes of Antimalarial-Refractory Cutaneous Lupus Erythematosus$

research Characteristics and Alternative Treatment Outcomes of Antimalarial-Refractory Cutaneous Lupus Erythematosus

16 citations, June 2017 in “JAMA Dermatology”

Thalidomide works best for skin lupus not helped by antimalarials, but has many side effects; other treatments are less effective, especially if patients also have systemic lupus.

research Discoid Lupus Erythematosus of the Scalp in a Patient with Systemic Lupus Erythematosus: A Case Report with Complete Hair Regrowth

June 2021 in “Revista da Sociedade Portuguesa de Dermatologia e Venereologia”

A patient with lupus experienced complete hair regrowth after treatment with thalidomide.

research Lichen Planus

155 citations, June 2009 in “International Journal of Dermatology”

Lichen planus is a skin condition that can resolve on its own, is linked to hepatitis C, and increases the risk of skin cancer.

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community Pyrilutamide vs enzalutamide. Same thing?( Especially for biochemists, farmacologists)

in Research/Science 17 upvotes 2 years ago

Researching whether pyri and enza, which are stereoisomers of each other, share the same features related to CNS penetration/GABA Inhibition; safety and efficacy when used topically at 0.5-1%; and cost comparison between the two treatments.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 151 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.