Cutaneous Lupus Erythematosus: Clinico-Pathologic Correlation

March 2018 in “ Italian Journal of Dermatology and Venereology ”

Raffaele Filotico, Valentina Mastrandrea

TLDR Cutaneous lupus erythematosus is a chronic skin disease that can progress to systemic lupus in some cases and requires treatment to prevent recurrences and scarring.

Cutaneous lupus erythematosus (CLE) was described as a chronic-relapsing autoimmune disease localized to the skin, with an annual incidence of 4 cases per 100,000 persons and a prevalence of 73 cases per 100,000 persons. The etiology remained unknown, but genetic, environmental, and pharmacological factors played significant roles. CLE was classified into acute, subacute, chronic, and intermittent forms, with skin lesions categorized as LE specific or non-specific. Histopathological features included interface dermatitis, lymphocytic infiltrate, hyperkeratosis, and PAS-positive material deposits. The progression of CLE to systemic lupus erythematosus (SLE) occurred in 12-18% of cases. Treatment focused on preventing recurrences and scarring, emphasizing photoprotection and using topical steroids, calcineurin inhibitors, and systemic hydroxychloroquine.

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