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GlossaryLymphocytic Infiltrate

accumulation of immune cells in tissue causing inflammation

Lymphocytic infiltrate refers to the accumulation of lymphocytes, a type of white blood cell, in a particular tissue. This often occurs as part of the body's immune response to infection, inflammation, or autoimmune conditions, where the immune system mistakenly attacks healthy cells. In the context of hair and alopecia, lymphocytic infiltrate can be seen in conditions like alopecia areata, where these immune cells target hair follicles, leading to hair loss.

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research Histologic Features of Alopecia Areata Other Than Peribulbar Lymphocytic Infiltrates

53 citations, September 2011

Other common signs, not just the well-known immune cells around hair bulbs, are important for diagnosing hair loss from alopecia areata.

research Diagnostic Usefulness of a Peribulbar Eosinophilic Infiltrate in Alopecia Areata

19 citations, September 2014 in “JAMA Dermatology”

Eosinophilic infiltrate is not a reliable indicator for diagnosing chronic alopecia areata.

research Alopecia Areata with Lymphocytic Mural Folliculitis Affecting the Isthmus in a Thoroughbred Mare

14 citations, August 2004 in “Veterinary Dermatology”

The horse had a rare type of hair loss caused by immune cells attacking hair follicles.

research Lymphocytic Mural Folliculitis Resembling Epitheliotropic Lymphoma in Tigers (Panthera Tigris)

April 2018 in “Veterinary Pathology”

Tigers had a skin condition causing hair loss and inflammation, but the cause is unknown and treatment didn't work.

research Overview of Common, Rare, and Atypical Manifestations of Cutaneous Lupus Erythematosus and Histopathological Correlates

157 citations, August 2010 in “Lupus”

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 2 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 5 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.