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GlossaryPerifollicular Lymphocytic Infiltrate

presence of immune cells around hair follicles

Perifollicular Lymphocytic Infiltrate refers to the presence of immune cells, specifically lymphocytes, around hair follicles. This condition is often seen in various types of hair loss disorders, such as alopecia areata, where the immune system mistakenly attacks the hair follicles, leading to hair loss.

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research Perifollicular Inflammation and Follicular Spongiosis in Androgenetic Alopecia

1 citations , September 2021 in “Journal of The American Academy of Dermatology”

Hair loss in both Androgenetic Alopecia and Alopecia Areata is often accompanied by inflammation around hair follicles, but the location and severity of this inflammation varies.

Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

research Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

January 2026 in “Clinical Cosmetic and Investigational Dermatology”

Early diagnosis and targeted anti-inflammatory treatments can improve outcomes in androgenetic alopecia with perifollicular inflammation and fibrosis.

research A Histologic Review of 27 Patients with Lichen Planopilaris

76 citations , June 2008 in “Journal of the American Academy of Dermatology”

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

research The Functional Relevance of the Type 1 Cytokines IFN-γ and IL-2 in Alopecia Areata of C3H/HeJ Mice

20 citations , November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

IFN-γ and IL-2 are important for T cell activation in hair loss in mice.

research Alopecia Mucinosa

20 citations , April 1959 in “A M A Archives of Dermatology”

Alopecia mucinosa causes red, raised skin patches and hair loss.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 413 upvotes 9 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 1 year ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

in Research/Science 11 upvotes 1 year ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

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