Ectrodactyly, Soft-Tissue Syndactyly, and Nodulocystic Acne: Coincidence or Association?

The document reported a case of a 21-year-old man with severe nodulocystic acne, ectrodactyly of the right foot, and soft-tissue syndactyly of the third and fourth left fingers and the first to fourth left toes. His acne was resistant to conventional treatments but showed moderate improvement with systemic isotretinoin. The authors discussed the differences between this case and Apert syndrome, which also involves syndactyly and acneiform eruptions. They suggested a possible link between acne lesions and bone deformities, potentially due to mutations in the fibroblast growth factor receptor 2 and the role of keratinocyte growth factor in hair follicle development.