Cutaneous Manifestations in Biologically Treated Inflammatory Bowel Disease Patients: A Narrative Review

    March 2021 in “ Journal of clinical medicine ”
    Jo Lambert, Sofie De Schepper, Reinhart Speeckaert
    Image of study
    TLDR Biologic treatments for Crohn's disease and ulcerative colitis can cause skin problems, and doctors should adjust treatment if these occur.
    The review from March 2021 discussed the skin-related side effects of biologic treatments for Crohn's disease and ulcerative colitis, which target TNF-α and Th17 pathways. These side effects include a range of conditions such as infusion reactions, eczema, psoriasis, lupus, alopecia areata, vitiligo, lichenoid reactions, granulomatous disorders, vasculitis, skin cancer, and infections. It emphasized the importance of recognizing these adverse reactions to adjust treatment strategies, which may involve topical treatments or changing the biologic therapy. TNF-α antagonists were noted to have the highest rate of adverse skin eruptions, followed by ustekinumab and anti-integrin receptor blockers. The review aimed to guide clinicians in identifying and managing these skin conditions in patients with inflammatory bowel disease.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 5 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    1 / 1 results