Alopecia Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy

    Lara Beatriz Prata Ribeiro, Juliana Carlos Gonçalves Rego, Bruna Duque Estrada, Paula Raso Bastos, Juan Piñeiro‐Maceira, Celso Tavares Sodré
    TLDR Anti-TNF therapy can cause hair loss and skin issues.
    The document described two cases of alopecia induced by infliximab, an anti-TNF therapy, in patients with Crohn's disease. Both patients developed psoriasiform lesions and alopecia plaques on the scalp, showing features of both alopecia areata and psoriatic alopecia. Treatment with topical corticosteroids and other medications resulted in hair regrowth and remission of skin lesions, while infliximab therapy was continued. This report emphasized the need to recognize this adverse effect for proper management and noted it as the first description of such cases in the national literature.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  821 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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