Thyroid Diseases and Skin Autoimmunity

The document from June 15, 2018, explores the connection between thyroid diseases (TD), especially autoimmune thyroid diseases (AITD) like Hashimoto thyroiditis and Graves' disease, and autoimmune skin diseases (AISD) such as pemphigus, bullous pemphigoid, vitiligo, and alopecia areata. It reports that AITD is the most common autoimmune disorder with a prevalence of about 5% and discusses the genetic and environmental factors involved in both AITD and AISD. The paper presents epidemiological evidence of a significant association between TD and AISD, suggesting shared molecular mechanisms in their pathogenesis. It also suggests that routine screening for TD in patients with AISD could be beneficial due to the strong evidence of association, indicating shared pathogenetic mechanisms. The document concludes that disruptions in thyroid hormone action may contribute to the progression of AISD and emphasizes the need for further research on the relationship between dysregulated thyroid hormone action and AISD. No specific studies with participant numbers are mentioned in the summary provided.