Thyroid Hormone Action in Epidermal Development and Homeostasis and Its Implications in the Pathophysiology of the Skin

    March 2021 in “ Journal of endocrinological investigation ”
    Giuseppina Mancino, Caterina Miro, Emery Di Cicco, Monica Dentice
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    TLDR Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.
    The document from March 8, 2021, discusses the role of thyroid hormones (THs), specifically T3 and T4, in the development and maintenance of skin homeostasis. It highlights that while T4 is produced in greater amounts, T3 is the more active form, and their levels are regulated not just centrally but also peripherally. The skin is significantly affected by THs, and various skin conditions, including alopecia, dermatitis, vitiligo, and eczema, are associated with thyroid disorders such as thyroiditis and Graves' disease. Recent studies have begun to uncover the molecular mechanisms by which THs influence keratinocyte proliferation and differentiation. The document aims to address unanswered questions in this area, with new insights being gained through the use of mouse models with altered TH metabolism, enhancing the understanding of TH metabolism's impact on skin pathophysiology.
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