Thyroid Hormone Action in Epidermal Development and Homeostasis and Its Implications in the Pathophysiology of the Skin
March 2021
in “
Journal of endocrinological investigation
”
thyroid hormones T3 T4 skin homeostasis alopecia dermatitis vitiligo eczema thyroiditis Graves' disease keratinocyte proliferation keratinocyte differentiation triiodothyronine thyroxine hair loss skin balance skin inflammation skin depigmentation skin rash thyroid inflammation autoimmune thyroid disease skin cell growth skin cell specialization
Studysummary This review covers the connection between thyroid diseases and skin conditions like alopecia, dermatitis, and vitiligo, and highlights the need for further research on the role of thyroid hormones in skin health. Our plain-language summary of this paper — not a Tressless recommendation.
The document from March 8, 2021, discusses the role of thyroid hormones (THs), specifically T3 and T4, in the development and maintenance of skin homeostasis. It highlights that while T4 is produced in greater amounts, T3 is the more active form, and their levels are regulated not just centrally but also peripherally. The skin is significantly affected by THs, and various skin conditions, including alopecia, dermatitis, vitiligo, and eczema, are associated with thyroid disorders such as thyroiditis and Graves' disease. Recent studies have begun to uncover the molecular mechanisms by which THs influence keratinocyte proliferation and differentiation. The document aims to address unanswered questions in this area, with new insights being gained through the use of mouse models with altered TH metabolism, enhancing the understanding of TH metabolism's impact on skin pathophysiology.
