TLDR Thyroid function affects skin health, with a complex interaction between the two.
In the 2010 article, the authors explored the "thyroid-skin connection," revealing that thyroid function impacts skin health, with both hypo- and hyperthyroid states potentially causing hair loss and other skin changes. They found that thyrotropin (TSH) receptors are present in human skin, indicating a direct effect of TSH on the skin, and suggested that the skin might also produce hormones that influence the hypothalamic-pituitary-thyroid (HPT) axis. The possibility that autoantibodies stimulating TSH-R could affect skin in autoimmune thyroid disease was discussed, as well as the expression of thyroid-specific genes in the skin and the potential production of TSH and thyrotropin-releasing hormone (TRH) by the skin. These findings suggest a complex interaction between thyroid function and skin health, with potential implications for autoimmune thyroid disease. Additionally, the document mentions the role of heat shock protein 27 (HSP27) in keratinocyte differentiation, indicating its involvement in cell signaling and cytoskeleton organization.
54 citations,
March 2009 in “BioEssays” Hormones control keratin production in skin and hair.
115 citations,
August 2008 in “The Journal of Clinical Endocrinology & Metabolism” Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.
253 citations,
December 2007 in “Journal of Investigative Dermatology” Hair follicles prevent NK cell attacks to avoid hair loss.
155 citations,
December 2002 in “Journal of Investigative Dermatology” Thyroid-related genes are active in skin cells and may affect autoimmune conditions.
111 citations,
April 2000 in “British journal of dermatology/British journal of dermatology, Supplement” Thyroid hormone receptor β1 is found in human hair follicles and helps them survive.
9 citations,
July 2020 in “Experimental Dermatology” Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.
2 citations,
September 2016 in “Journal of evolution of medical and dental sciences” Thyroid problems are linked to various skin issues, and checking thyroid health is important for people with certain skin conditions.
October 2023 in “Clinical medicine and medical research” Thyroid function may influence hair loss after COVID-19.
October 2022 in “Southeast Asian journal of health professionals” Hair greying is seen as a sign of aging; temporary fixes like hair dye are used, but a balanced diet and hair care can help manage it.
October 2024 in “Journal of the Endocrine Society” A woman experienced fluctuating thyroid conditions and eye disease, but her symptoms improved with treatment.
