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    Glossary Heat Shock Protein 27

    small protein that helps protect cells from stress

    Heat Shock Protein 27 (HSP27), also known as HSPB1, is a small protein that helps protect cells from stress by preventing the aggregation of damaged proteins and assisting in their proper folding. It plays a crucial role in cellular responses to heat shock, oxidative stress, and other environmental stressors, and is also involved in processes like apoptosis (programmed cell death) and inflammation.

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    1. Expression of the heat shock protein-27 in the adult human scalp skin and hair follicle: Hair cycle–dependent changes Journal of the American Academy of Dermatology · 2006 · 24 citations
    2. Up-regulation of androgen receptor by heat shock protein 27 and miR-1 induces pathogenesis of androgenic alopecia. PubMed · 2022
    3. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    4. Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009 · 49 citations
    5. Effects of dihydrotestosterone on rat dermal papilla cells in vitro European Journal of Pharmacology · 2015 · 19 citations
    6. Editorial: Inflammation, stem cells and wound healing in skin aging Frontiers in Cell and Developmental Biology · 2022
    7. Susan Lee Lindquist (1949–2016)—pioneer in the study of cellular protein folding and disease EMBO journal · 2016 · 2 citations
    8. Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2. PubMed · 1992 · 31 citations
    9. The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature International Journal of Molecular Sciences · 2023 · 3 citations
    10. Elevated serum heat shock protein-70 and interleukin-15: prognostic biomarkers correlating with clinical severity and diagnostic efficacy in active alopecia areata Journal of the Egyptian Womenʼs Dermatologic Society · 2026
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