Diffuse Alopecia and Thyroid Atrophy Associated with Selenium and Zinc Deficiency in Sheep

February 2019 in “ Americanae (AECID Library) ”

Rubia Ávlade Guedes Sampaio

alopecia selenium deficiency zinc deficiency thyroid hormones T3 T4 thyroid gland atrophy hyperkeratosis skin abnormalities

TLDR Selenium and zinc deficiency in sheep leads to thyroid and skin problems.

The study investigated the effects of selenium (Se) and zinc (Zn) deficiency on thyroid function and skin health in sheep. Five adult sheep with systemic syndrome and alopecia were examined, revealing low serum and liver levels of Se and Zn, and reduced concentrations of thyroid hormones T3 and T4. The sheep exhibited multifocal to coalescent alopecia, dry and brittle hair, and thickened skin with scabs and scaling. Necropsy showed cachexia, serous fat atrophy, and significant thyroid gland atrophy. Microscopically, the thyroid displayed atrophied and dilated follicles with macrophage infiltration and fibrous tissue. The skin showed hyperkeratosis, edema, and sweat gland ectasia. The study concluded that thyroid disease directly affected the skin due to thyroid hormones' interaction with skin receptors, highlighting the importance of mineral supplementation for maintaining body homeostasis.

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